个人介绍

脑病个性化防治跨学科研究所所长; 中医药调控脑-外周稳态与大健康粤港澳联合实验室主任; 博士生导师

职称：教授

研究方向： 经典名方个性化防治抑郁症，痴呆症的现代机制研究与应用转化

电子邮箱：chengang@jnu.edu.cn

Name: Chen Gang

Director of the Interdisciplinary Institute for Personalized Medicine on Brain Disorders; Director of the GHM Joint Laboratory of Traditional Chinese Medicine on Brain-Peripheral Homeostasis and Comprehensive Health

Title: Professor

Research Focus: the mechanic and translational research on personalized prevention and treatment of depression and dementia by using Traditional Chinese Medicine, particularly Classical Herbal Formulas

Email：chengang@jnu.edu.cn

获美国罗格斯大学心理学博士。重点从事经典名方（如越鞠丸，好忘方等）优势性抗抑郁抗痴呆的现代机理与复方物质基础与转化研究，主持国家重点研发计划等多项国家及省级重点课题，一作/通讯作者发表中英文杂志论文各40余篇，主持或报告海外学术会议10余场。任中国生理学会中医药与脑稳态调控专委会创会主任委员，中华中医药学会中基分会常务理事，国际脑与行为遗传学会常务理事等。获省特聘教授，省双创团队领军人才等称号。

Professor Chen received a Ph.D. in Psychology from Rutgers University in the United States. His research focuses on  the current molecular and system mechanisms and compound substance basis of classical Chinese herbal formulas (such as Yueju Pill and Haowang Formula)  in combating depression and dementia like Alzheimer’s Disease, with their advantages being scientifically revealed. He has been awarded with multiple national and provincial key research project grants, including the National Key Research and Development Program. He has published over 40 research papers in both Chinese and English journals as the first author or corresponding author, and presented at more than 10 international academic conferences. He has served as the Founding Chairman of the Chinese Physiological Society’s Committee on Traditional Chinese Medicine and Brain Homeostasis Regulation, executive council member of the Committee on Theory Foundation of Traditional Chinese Medicine of Chinese Association of Traditional Chinese Medicine, and member-at-large of the International Society of Brain and Behavior Genetics. He has been honored as a Distinguished Provincial Professor and the Leader of a provincial Innovation and Entrepreneurship Talent Team.

科研成果

陈刚教授自2012年以来，首次揭示中药越鞠丸快速抗抑郁效用，特定机制及相互作用物质基础。以该研究为代表，针对现有主流医学在治疗抑郁症，老年痴呆等严重脑病上存在的明显问题，通过深入系统发掘特定经典名方的潜在优势，对其功效的个性化差异及特定机理进行创新性阐释，并探索出基于复方核心机制靶标科学揭示其靶向协同成分的复方物质基础的新研究方法，提出并建立中医证候与疾病的共易感性及其研究模型，揭示中医药辨证论治的科学内涵，并创制了新的抑郁症痴呆症的预防和治疗手段。

①代表性课题：

2022-2024   科技部战略性科技创新合作重点专项“中药复方有效成分协同激活主效靶点PACAP介导快速持久抗抑郁机制与应用研究” 200万

2022-2025   国家自然科学基金面上项目“海马齿状回GLP-1-PACAP信号级联调控越鞠丸快速抗抑郁机制研究”55万

2019-2022   国家自然科学基金面上项目（动物模型）“基于抑郁症和气虚证应激共易感性的病证结合动物模型研究” 81万

2017-2019   江苏双创团队项目主持人  300万

②代表性论文(Representative papers)：

Zhang H, Sun Y, Yau SY, Zhou Y, Song X, Zhang HT, Zhu B, Wu H*, Chen G*. Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up-regulating hippocampal PACAP signaling. Br J Pharmacol. 2022 Mar 31. doi: 10.1111/bph.15847. Epub ahead of print. PMID: 35362097.

Zhang Y, Cui B, Wang T, Lu Y, Chen Z, Zou Z, Miao J, Zhao X, Yuan Y, Wang H*, Chen G*. Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy. Front Behav Neurosci. 2021 Oct 27;15:712445. doi: 10.3389/fnbeh.2021.712445. PMID: 34776888; PMCID: PMC8578865.

Tang J, Lu L, Wang Q, Liu H, Xue W, Zhou T, Xu L, Wang K, Wu D, Wei F, Tao W, Chen G*. Crocin Reverses Depression-Like Behavior in Parkinson Disease Mice via VTA-mPFC Pathway. Mol Neurobiol. 2020 Jul;57(7):3158-3170.

Chen G*, Xue WD, Zhu J 2018 Full genetic analysis for genome-wide association study of Fangji: a powerful approach for effectively dissecting the molecular architecture of personalized traditional Chinese medicine. Acta Pharmacol Sin. 2018 Feb 8. doi: 10.1038/aps.2017.137

Wu R, Zhang H, Xue W,  Zou ZL, Lu C,  Xia B, Wang W, Chen G* 2016 Transgenerational impairment of hippocampal Akt-mTOR signaling and behavioral deficits in the offspring of mice that experience postpartum depression-like illness. Prog Neuropsychopharmacol Biol Psychiatry. 28;73:11-18

Tang J, Xue W, Xia B, Ren L, Tao W, Chen C, Zhang H, Wu R, Wang Q, Wu H, Duan J, Chen G*. 2015 Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice. Sci Rep. 2015 28;5:13573.

Xue W, Zhou X, Yi N, Jiang L, Tao W, Wu R, Wang D, Jiang J, Ge X, Wang Y, Wu H, Chen G*. 2013. Yueju pill rapidly induces antidepressant-like effects and acutely enhances BDNF expression in mouse brain. Evidence-Based Complementary and Alternative Medicine. 2013:184367

王省，陈刚，试论枢转少阳与快速抗抑郁，中医杂志，2017年第58卷第2期：174-176

王旭东,乔明琦,张樟进,陈刚,陈家旭,图娅.中医药治疗抑郁症的研究进展.南京中医药大学学报,2016,32(1):93-96.

获奖及荣誉

1、江苏省特聘教授

2、江苏省双创人才

3、江苏省双创团队领军人才

江苏省中医药领军人才

2022广东省科技进步二等奖（排名第四）

学术兼职

中国生理学会中医药与脑稳态调控专委会首任主任委员及中国生理学会理事；

中华中医药学会中医基础理论分会常务理事；

世界中医药联合会李时珍医药应用与研究专业委员会和心身医学专业委员会常务理事；

国际行为和神经遗传学会（IBANGs）执行理事（Member-at-large）兼会员委员会主席（2020-2023）；

粤港澳脑病中医药产学研创新技术联盟副理事长兼秘书长

广东省精准医学会阿尔兹海默症分会副主委；

美国神经科学学会（SFN）会员等；

《脑，行为，免疫-整合》（《Brain，Behavior， Immunity-Integrative》）杂志副主编；

《环球中医药》杂志编辑等