副教授,博士研究生导师,研究方向:高血压、糖尿病肾病等慢性病的中西医结合防治研究 电子邮箱: xiaoy527@jnu.edu.cn
姓名:肖雅
职称:副教授
研究方向:高血压、糖尿病肾病等慢性病的中西医结合防治研究
电子邮箱:xiaoya0527@126. com
肖雅,女,医学博士,副教授,博士研究生导师。任职为广东省中西医结合学会活血化瘀专业委员会常委、肾病专业委员会委员、亚健康专业委员会委员,广东省中医药学会中医基础理论专业委员会委员。从事中医基础理论、循证中医药学教学。近年来主持国家自然科学基金3项,省部级课题4项。参编专著3部,发表学术论文30余篇,其中以第一作者/通讯作者身份发表SCI论文20余篇。担任Phytomedicine、Journal of Ethnopharmacology、Biomedicine& Pharmacotherapy等国际期刊特邀审稿人。
更新时间:2024年9月3日
①课题:
1.国家自然科学基金面上项目,82374231,TRIM24泛素化修饰ATF4在高盐诱导高血压病血管内皮细胞功能障碍中的作用及桃红四物汤的干预效应,2024/01-2027/12,49万元,主持
2.国家自然科学基金面上项目,82074307,基于LncRNA NFE2L2/miR-1931探讨益气养阴活血法调控糖尿病肾病内质网自噬的机制研究,2021/01-2024/12,55万元,主持
3.国家自然科学基金青年基金项目,81603520,基于内质网应激-自噬途径探讨益气养阴活血法防治糖尿病肾病的分子机制,2017/01-2019/12,17万元,主持
4.广东省自然科学基金项目,2023A1515011949,桃红四物汤通过ATF4/HSPA5通路调控肾小球内皮细胞铁死亡防治高血压肾损伤的机制研究,2023/01-2025/12,10万元,主持
5.广东省自然科学基金项目,2017A030313658,从内质网应激-自噬途径探讨芪丹地黄颗粒防治糖尿病肾病的分子机制,2017/05-2020/05,10万元,主持
6.广州市科技计划项目,201804010213, 基于ATF4信号通路介导的内质网应激-自噬失衡探讨芪丹地黄颗粒治疗糖尿病肾病的作用机制,2018/04-2021/03,20万元,主持
7.广东省自然科学基金博士启动项目,2016A030310084,miR-103/Insig1-SCAP-SREBP通路介导的脂代谢紊乱在妊娠期糖尿病中的作用及枸杞提取物的干预研究,2016/06-2019/06,10万元,主持
②论文:
[1] Xie T, Bai Z, Chen Z, Liang H, Liu T, Lam LK, Xu P, Xie P, Chen L*, Xiao Y*. Inhibition of ferroptosis ameliorates hypertensive nephropathy through p53/Nrf2/p21 pathway by Taohongsiwu decoction: Based on network pharmacology and experimental validation. J Ethnopharmacol. 2023:116506.
[2] Bai Z, Xie T, Liu T, Chen Z, Yu L, Zhang C, Luo J, Chen L*, Zhao X*, Xiao Y*. An integrated RNA sequencing and network pharmacology approach reveals the molecular mechanism of dapagliflozin in the treatment of diabetic nephropathy. Front Endocrinol (Lausanne). 2022 ;13:967822.
[3] Liang Q, Bai Z, Xie T, Lu H, Xiang L, Ma K, Liu T, Guo T, Chen L*, Zhao X*, Xiao Y*. Deciphering the Pharmacological Mechanisms of Qidan Dihuang Decoction in Ameliorating Renal Fibrosis in Diabetic Nephropathy through Experimental Validation In Vitro and In Vivo. Evid Based Complement Alternat Med. 2022;2022:4137578.
[4] Liang Q, Liu T, Guo T, Tao W, Chen X, Chen W, Chen L*, Xiao Y*. ATF4 promotes renal tubulointerstitial fibrosis by suppressing autophagy in diabetic nephropathy. Life Sci. 2021;264:118686.
[5] Liu TH, Tu WQ, Tao WC, Liang QE, Xiao Y*, Chen LG*. Verification of Resveratrol Inhibits Intestinal Aging by Downregulating ATF4/Chop/Bcl-2/Bax Signaling Pathway: Based on Network Pharmacology and Animal Experiment. Front Pharmacol. 2020;11:1064.
[6] Liu TH, Chen MH, Tu WQ, Liang QE, Tao WC, Jin Z, Xiao Y*, Chen LG*. Network and 16S rRNA Sequencing-Combined Approach Provides Insightal Evidence of Vitamin K2 for Salt-Sensitive Hypertension. Front Nutr. 2021;8:639467.
[7] Liu TH, Tao WC, Liang QE, Tu WQ, Xiao Y*, Chen LG*. Gut Microbiota-Related Evidence Provides New Insights Into the Association Between Activating Transcription Factor 4 and Development of Salt-Induced Hypertension in Mice. Front Cell Dev Biol. 2020;8:585995
[8] Liu TH,Xie T, Bai Z, Liang QE, Xie Pengcheng, Xue Yuzheng,, Xiao Y*, Chen LG*. The Important Role of TaohongSiwu Decoction in Gut Microbial Modulation in Response to High-Salt Diet-Induced Hypertensive Mice.Natural Product Communications.2022; 17(8): 1–11.
广东省中西医结合学会活血化瘀专业委员会常委
广东省中西医结合学会肾病专业委员会委员
广东省中西医结合学会亚健康专业委员会委员
广东省中西医结合学会活血化瘀专业委员会委员
广东省中医药学会中医基础理论专业委员会委员