个人简介

李永欣，男，理学博士，硕士生导师。近年来主要关注于医学影像技术在神经系统疾病的应用研究，从临床的实际问题出发，通过多模态核磁共振成像方法对抑郁症、脑卒中和儿童癫痫等常见神经疾病的影像学表现以及治疗前后的影像学变化进行研究，以期加深对相关疾病的内在神经机制的理解，为临床活动提供影像学方面的指导，服务于临床诊疗工作。整体研究工作偏重于基础研究，在此基础上寻找临床应用转换的潜在价值。

教学/科研成果

①课题：

1. 广东省医学科研基金项目，基于静息态功能磁共振成像动态脑网络技术对儿童特发性全身性癫痫发病机制的研究，202011249354630, 2021.07.01-2023.06.30，1万元，主持

2. 国家自然科学基金青年科学基金项目，81601483，基于多模态神经影像学的特发性全身性儿童癫痫脑网络的研究，2017/01-2019/12，17万，主持

3. 中国博士后科学基金面上项目，2017M610538, 多模态磁共振成像对儿童特发全身性癫痫脑网络的研究, 2016/03-2018/12, 8万，主持

4. 中国博士后科学基金面上项目，2015M572337，多参数时空动态成像系统对活体肺癌组织代谢机制的研究，2015/01-2016/12，5万，主持

5. 国家自然科学基金重大仪器专项基金项目，61427807，活体肿瘤组织代谢信号多参数时空动态成像系统研究，2015/01-2019/12，510万，参与

6. 广东省自然科学基金，2016A030310402，基于多模态神经影像学的特发性全身性儿童癫痫脑网络的研究，2016/06-2019/6，10万，主持

②论文：

1. Li, Yongxin, Yu, Zeyun, Wu, Ping, Chen, Jiaxu. (2021). The disrupted topological properties of structural networks showed recovery in ischemic stroke patients: a longitudinal design study. BMC Neuroscience. 2021, 22: 47.

2. Yongxin Li*, Qian Chen, Wenhua Huang, Disrupted topological properties of functional networks in epileptic children with generalized tonic-clonic seizures. Brain and Behavior, 2020: e01890.

3. Huang Jiabin#, Li Yongxin#*, Xie Huijun, Yang Shaomin, Jiang Changyu, Sun Wuping, Li Disen, Liao Yuliang, Ba Xiyuan, Xiao Lizu*, Abnormal Intrinsic Brain Activity and Neuroimaging-Based fMRI Classification in Patients With Herpes Zoster and Postherpetic Neuralgia, Frontiers in Neurology, 2020, 11(1181): 532110

4. Yongxin Li*, Ya Wang, Yanfang Wang, Huirong Wang, Ding Li, Qian Chen, Wenhua Huang*, Impaired topological properties of gray matter structural covariance network in epilepsy children with generalized tonic-clonic seizures: A graph theoretical analysis, Frontiers in neurology, 2020, 11: 253.

5.Yongxin Li*, Zhen Tan, Z, Ya Wang, Yanfang Wang, Ding Li, Qian Chen, Wenhua Huang. Detection of differentiated changes in gray matter in children with progressive hydrocephalus and chronic compensated hydrocephalus using voxel-based morphometry and machine learning.  Anatomical Record. 2020; 303: 2235– 2247.

6.Jianping Wang, Yongxin Li*, Ya Wang, Wenhua Huang, Multimodal data and machine learning for detecting specific biomarkers in pediatric epilepsy patients with generalized tonic-clonic seizures, Frontiers in neurology, 2018, 9: 1038.

7. Yongxin Li, Ya Wang, Zhen Tan, Ding Li, Qian Chen*, Wenhua Huang*, Longitudinal brain functional and structural connectivity changes after hemispherotomy in two pediatric patients with drug-resistant epilepsy, Epilepsy & Behavior Case Reports, 2019, 11: 58-66. 

8.  Yongxin Li#, Zhen Tan#, Jianping Wang, Ya Wang, Yungen Gan,  Feiqiu Wen,  Qian Chen*, Derek Abbott, Kelvin K. L. Wong,Wenhua Huang*, Alterations in Spontaneous Brain Activity and Functional Network Reorganization following Surgery in Children with Medically Refractory Epilepsy: A Resting-State Functional Magnetic Resonance Imaging Study, Frontiers in neurology, 2017, 8: 374.

9. Ya Wang, Yongxin Li*, Huirong Wang, Yanjun Chen, Wenhua Huang*, Altered Default Mode Network on Resting-State fMRI in Children with Infantile Spasms, Frontiers in Neurology, 2017, 8: 209.

10.Yongxin Li, Ya Wang, Chenxi Liao, Wenhua Huang*, Ping Wu*, Longitudinal brain functional connectivity changes of the cortical motor-related network in subcortical stroke patients with acupuncture treatment,Neural Plasticity, 2017, 2017: 5816263.

11.Yongxin Li#, Defeng Wang#, Heye Zhang, Ya Wang, Ping Wu, Hongwu Zhang, Yang Yang, Wenhua Huang*. Changes of Brain Connectivity in the Primary Motor Cortex after Subcortical Stroke: A Multimodal MRI Study. Medicine, 2016，95(6):e2579

12.Yongxin Li, Feiyan Chen, Wenhua Huang*, Neural plasticity following abacus training in humans: a review and future directions, Neural Plasticity, 2016, 2016: 1213723

13.Yongxin Li, Cailei Zhao, Zhen Tan, Ya Wang, Heye Zhang, Jinyang Wang, Honghua Guo, Baozhen Zeng, Wenhua Huang*. Longitudinal changes in the brain following third ventriculostomy in a child with hydrocephalus: case report, Medicine, 2015, 94(47): e2095.

14.Yongxin Li#, Ya Wang#, Heye Zhang, Ping Wu*, Wenhua Huang*.The effect of acupuncture on the motor function and white-matter microstructure in ischemic stroke patients, Evidence-Based Complementary and Alternative Medicine, 2015, 2015:164792.

15.李永欣,刘哲星，黄文华等. 扩散张量成像数据分析方法概述. 中国医学影像技术2015, 31(6): 134-137.

16.Zhen Tan#, Yongxin Li#, Fengjun Zhu, Dongdong Zang, Cailei Zhao, Cong Li, Dan Tong, Heye Zhang*, Qian Chen*，Children with Intracranial Arachnoid Cysts: Classification and Treatment， Medicine， 2015, 94(44): e1749

17.Yongxin Li #, Ping Wu#, Fanrong Liang*, Wenhua Huang*, The microstructural status of the corpus callosum is associated with the degree of motor function and neurological deficit in stroke patients, Plos one, 2015, 10(4): e0122615.

18.Yongxin Li, Yuzheng Hu, Ming Zhao, Yunqi Wang, Jian Huang, Feiyan Chen*, The neural pathway underlying a match-to-sample task in abacus-trained children and associated functional connectivity in the resting brain, Brain Research, 2013, 1539: 24-33.

19.Yongxin Li, Yunqi Wang, Yuzheng Hu, Feiyan Chen*, Structural changes in left fusiform areas and associated fiber connections in children receiving abacus training: Evidence from morphometry and tractography, Frontiers in Human Neuroscience, 2013, 7: 00335.

20.Yongxin Li, Yuzheng Hu, Jian Weng, Wangyun Qi, Feiyan Chen*, Individual structural differences in left inferior parietal area are associated with schoolchildrens’ arithmetic scores; Frontiers in Human Neuroscience, 2013, 7: 00844.

专著：

系统解剖学,北京：科学出版社 2018.05, 编者

学术兼职

自2018年6月聘任为广东省生物医学工程学会生物力学分委会委员。