研究方向:湿证/湿热证相关疾病研究。 电子邮箱:dengli@jnu.edu.cn
研究方向:湿证/湿热证相关疾病研究。 电子邮箱:dengli@jnu.edu.cn
姓名:邓力
职称:教授
研究方向:湿证/湿热证相关疾病研究
电子邮箱:dengli@jnu.edu.cn
医学博士,教授,广东省杰出青年基金项目获得者,王宽诚青年学者。暨南大学中医学院,博士研究生导师,主要从事湿热证的相关病因病机、中药复方及其有效成分防治湿热证相关机制研究。主持国家自然科学基金2项,省部级课题6项(具体见科研成果)。近年来相关研究成果共发表论文40余篇,以通讯作者或第一作者身份(含共同)发表较高影响因子SCI论文20余篇,其中IF 10分以上论文6篇,最高影响因子21.30分,中国科学院1区/TOP论文17篇,申请专利2项,授权专利1项。
① 课题:
1.国家自然科学基金,面上项目,基于SUCNR1/FLT4介导的巨噬细胞代谢重编程探讨宣白承气汤治疗流感合并S.pn共感染的机制,45万,2024.01-2027.12,在研,主持
2.国家自然科学基金,青年项目,基于外泌体miRNA对M2型巨噬细胞极化的调控探讨湿邪致病病程缠绵的病机本质,24万,2021.01-2023.12,已结题,主持
3.广东省杰出青年基金项目,湿热证的生物学机制研究,100万,2025.01-2028.12,在研,主持
4.广东省自然科学基金,青年提升项目,基于SUCNR1对FLT4依赖性巨噬细胞代谢重编程的调控探讨宣白承气汤治疗流感合并S.pn共感染的机制,24万,2024.01-2026.12,在研,主持
5.广东省自然科学基金,面上项目,基于肠脑轴Ghrelin-NPY/AgRP神经通路探讨“湿阻中焦”的科学内涵,10万,2020.10-2023.09,已结题,主持
6.广东省自然科学基金,面上项目,基于外泌体miR-155对M2型巨噬细胞极化的调控探讨湿邪致病病程缠绵的病机本质,10万,2019.10-2022.09,已结题,主持
7.广东省中医药局,面上项目,葛根芩连汤对湿热型流感治疗作用及其主要药效成分作用机制的研究,2万,2020.01-2022.12,已结题,主持
8.广州市科技计划项目,基于外泌体miR-155对巨噬细胞焦亡的调控探讨湿邪致病缠绵病机的本质,5万,2022.04-2024.3,已结题,主持
9.暨南大学,中央高校基本科研业务费专项资金项目,葛根芩连汤对湿热型流感治疗作用及其主要药效成分作用机制的研究,10万,2019.01-2021.12,已结题,主持
10.基于肠道微生态的变化探讨湿热证的生物学基础及相关方剂的作用机制,294万,2019/01-2023.12,国家自然科学基金-重点项目,参与
11.基于不同饲养环境下流感小鼠肠道微生态的变化及脑肠互动探讨湿性重浊的病生机制,55万,2018/01-2021/12,国家自然科学基金-面上项目,参与
12.基于不同饲养环境下流感小鼠肠道微生态及肠道黏膜免疫的变化探讨湿性粘滞的本质,74万,国家自然科学基金-面上项目,参与
13.岭南湿证相关疾病辨证标准的系统研究,500万,2020/01-2024/01,广东省重点领域研发计划-重大项目,参与
② 论文:
1.Humid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in mice[J]. Nature Communications, 2024, 15(IF:17.69,中国科学院Top1区期刊)
2.A hierarchically assembled oral formulation with drug-convertible carriers for targeted ulcerative colitis therapy through a three-pronged strategy[J]. Advanced Composites and Hybrid Materials, 2025, 8: 280. (中国科学院Top期刊,IF:23.2)
3.1,8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex,Journal of Pharmaceutical Analysis, 2023 9, 13(IF:14.03,中国科学院1区Top期刊)
4.Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis, Metabolism. 2022 17;139. (IF:13.934, 中国科学院1区Top期刊)
5.Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4, Pharmacological Research. 2022;176. (IF:10.334, 中国科学院1区Top期刊)
6.Regular exercise ameliorates high-fat diet-induced depressive-like behaviors by activating hippocampal neuronal autophagy and enhancing synaptic plasticity. Cell Death & Disease. 2024;15.(IF:9.7,共同通讯作者,中国科学院Top1区期刊)
7.Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma. Free Radic Biol Med. 2023;203(IF:8.1,共同第一作者,中国科学院2区Top期刊)
8.Discovery of a SUCNR1 antagonist for potential treatment of diabetic nephropathy: In silico and in vitro studies. International Journal of Biological Macromolecules, 2024, 268(IF:8.2,共同通讯作者,中国科学院1区Top期刊)
9.Feruloylated Oligosaccharides Prevented Influenza-Induced Lung Inflammation via the RIG-I/MAVS/TRAF3 Pathway. Journal of Agricultural and Food Chemistry, 2024, 72(IF:6.1,第一作者,中国科学院1区Top期刊,封面论文)
10.Adlay (Coix lacryma-jobi L.) Polyphenol Improves Hepatic Glucose and Lipid Homeostasis through Regulating Intestinal Flora via AMPK Pathway, Mol. Nutr. Food Res. 2022, 66, 2200447. (IF: 6.575,中国科学院2区期刊,封面论文)
11.The predictive, preventive, and personalized medicine of depression: gut microbiota and inflammation. EPMA Journal, 2024, 15(IF:8.84,中国科学院2区Top期刊)
12.The gut-lung axis in influenza A: the role of gut microbiota in immune balance[J]. Frontiers in Immunology, 2023, 14(IF:8.79,中国科学院2区Top期刊)
13.Study of the Relationship between Mucosal Immunity and Commensal Microbiota: A Bibliometric Analysis. Nutrients, 2023, 15(IF:6.71,中国科学院2区Top期刊)
14.Poria cocos Polysaccharide Ameliorated Antibiotic-Associated Diarrhea in Mice via Regulating the Homeostasis of the Gut Microbiota and Intestinal Mucosal Barrier. International Journal of Molecular Sciences, 2023, 24(IF:6.21,中国科学院2区Top期刊)
15.GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora, Biomedicine & Pharmacotherapy. 2021;141 (IF:7.419,第一作者, 中国科学院2区Top期刊)
16.Proanthocyanidins attenuates ferroptosis against influenza-induced acute lung injury in mice by reducing IFN-γ, Life Sci. 2022 Dec 14;314:121279. (IF: 6.78)
17.Comparison Between Wedge Resection and Lobectomy/Segmentectomy for Early-Stage Non-small Cell Lung Cancer: A Bayesian Meta-analysis and Systematic Review, Annals Of Surgical Oncology, 2021, 29 (3) , pp.1868-1879 (IF: 5.344,中国科学院2区 Top期刊)
18.Herbal Medicine, Gut Microbiota, and COVID-19, Frontiers in Pharmacology, 2021 Jul 7;12:646560. ( IF:5.988)
19.Prolonged exposure to high humidity and high temperature environment can aggravate influenza virus infection through intestinal flora and Nod/RIP2/NF-κB signaling pathway, Vet Microbiol. 2020 Dec;251:108896. (中国科学院2区 Top期刊,第一作者)
20.Forsythoside A Controls Influenza A Virus Infection and Improves the Prognosis by Inhibiting Virus Replication in Mice. Molecules, 2016, 21(5), 524 (中国科学院2区 Top期刊,第一作者)
21.Comprehensive analysis of the gut microbiota in patients with chronic obstructive pulmonary disease of varying severity-A prospective, observational study. Heliyon, 2024, 10(共同第一作者,中国科学院3区期刊)
22.Prediction of exacerbation frequency of AECOPD based on next-generation sequencing and its relationship with imbalance of lung and gut microbiota: a protocol of a prospective cohort study. BMJ Open. 2021 Sep 2;11(9): e047202.
23.Network pharmacology and in vivo experiments reveal the pharmacological effects and molecular mechanisms of Simiao Powder in prevention and treatment for gout, BMC Complement Med Ther. 2022 Jun 7;22(1):152.
24.Single Acupuncture Treatment Can Reduce the Level of Uric Acid and Alleviating Pain in Gouty Arthritis, a Meta-Analysis, Acupuncture & Electro-Therapeutics Research, 2021, 46 (2), pp.147-158
25.Efficacy comparison of different acupuncture methods for herpes zoster A Bayesian analysis protocol, Medicine,2022 99 (26)
26.Identification of Potential Biomarkers of Depression and Network Pharmacology Approach to Investigate the Mechanism of Key Genes and Therapeutic Traditional Chinese Medicine in the Treatment of Depression, Evid Based Complement Alternat Med. 2021 31;2021.
27.Potential Molecular Mechanisms of Plantain in the Treatment of Gout and Hyperuricemia Based on Network Pharmacology, Evid Based Complement Alternat Med. 2020 22;2
28.Dampness Can Promote the Influenza A Virus and Worsen Its Prognosis by Upregulating the TLR7 Signaling Pathway. Alternative Therapies in Health And Med. 2017 Jun 23.
29.The Effects of Iontophoretic Injections of Salvia miltiorrhiza on the Maturation of the Arteriovenous Fistula: A Randomized, Controlled Trial. Alternative Therapies In Health And Medicine, 2016, 22(5), 18-22
30.葛根芩连汤对肠道微生态的影响.中国中医药现代远程教育,2021,19(07):97-100. (通讯作者)
31.伪麻黄碱通过平息细胞因子风暴和抑制病毒复制保护H_1N_1感染的小鼠(英文)[J].上海中医药大学学报,2020,34(03):41-49. (第一作者)
32.新加香薷饮对湿热环境下流感病毒性肺炎小鼠治疗作用的比较研究[J]. 新中医, 2016,48(02): 235-238. (第一作者)
33.历代中医外感病因学发展探析[J]. 长春中医药大学学报,2014,30(03):377-380. (第一作者)
③ 专利:
1.一种酚酸酯类化合物的应用,发明人:黄俊卿;邓力;郑洁;欧隽滢;郝闻致(ZL 20 21 1 0321432. 2)) (本专利主要内容为酚酸酯类化合物治疗流感性肺炎的应用)
中国中医药研究促进会,温病与感染病分会,理事;
广东省中西医结合学会,转化医学专业委员会,常务委员;
广东省中西医结合学会,实验医学专业委员会,常务委员;
广东省中西医结合学会,活血化瘀专业委员会,委员;
广东省药理学会,内分泌代谢病药理专业委员会,常务委员;
广东省中医药学会,证候基础专业委员会,常务委员;
广东省医学会,老年医学分会,老年气道疾病防控与治疗学组成员。